Our Research

From our translational research developing the next generation proteasome inhibitor Kyprolis™ to the development of our PROTAC technology, we are focused on using chemical biology to explore cell biology and applying that knowledge to generate novel medicines and therapeutic strategies. Our lab uses a variety of approaches to explore different aspects of biology. These draw upon various disciplines such as cell biology, biochemistry, pharmacology, medicinal and organic chemistry as illustrated by the projects below.


Induced Protein Degradation (PROTACs)
Controlling intracellular protein levels using small molecules


The next generation proteasome inhibitor

Chemical Biology

Exploring cell biology using small molecules
Identify and validate new drug targets