Inducing Protein Degradation

Controlled Proteostasis [noun].   1. the control of protein function via the control of protein levels.  see also PROTACs

 

Our Proteolysis-Targeting Chimera (PROTAC) technology hijacks the cellular quality control machinery to tag unwanted intracellular proteins for degradation.  With better  pharmaceutic properties than siRNA and CRISPR, PROTACs offer a potentially new therapeutic modality by degrading pathogenic proteins (i.e.,‘making the problem proteins go away’).

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PROTAC

Our Research

From our translational research developing the next generation proteasome inhibitor KyprolisTM to the development of our PROTAC technology, we are focused on using chemical biology to explore cell biology and applying that knowledge to generate novel medicines and therapeutic strategies.