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The Broad Foci of the Crews Laboratory

A major focus of the lab is the application chemical approaches to the study of biological questions. Current projects explore the modes of action of biologically active natural products in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addtion, we are currently developing new small molecule-based methodologies for the control intracellular protein levels.

Our lab also investigates the molecular mechanisms of cell dedifferentiation and wound healing in regenerating limbs. Current projects focus on the development of in vitro models of urodele limb regeneration.