Proteasome Inhibitors

Since our initial discovery that the microbially-derived natural products epoxomicin and eponemycin represent a new class of proteasome inhibitors, we have focused on the development of additional inhibitors based on this epoxyketone proteasome-selective pharmacophore.  These studies have also led us to explore the chemistry and biology of other proteasome inhibitors such as the neurotrophic natural product fellutamide B and the natural product TMC-95A/B.

Relevant Publications

Myung J, Kim K, Lindsten KK, Dantuma NP, Crews CM
Molecular Cell 2001 7 2 411-420
Princiotta MF, Schubert U, Bacik I, Bennink JR, Myung J, Crews CM, Yewdell JW
Proc. Natl. Acad. Sci. USA 2001 98 2 513-518