Chemical Biology

Exploring Cell Biology using Small Molecules

Since 1995, our lab has probed different aspects of cell biology using biologically active natural products.  These mode of action studies have combined total syntheses and affinity reagent generation with biochemical, cell biological and pharmacological approaches in order to elucidate the molecular mechanisms by with certain natural product exert their biological activity.  This work has led to the identification and validation of new drug targets such as methionine aminopeptidase 2 (MetAP-2) as well as to new drug candidates such as the next generation proteasome inhibitor carfilzomib/Kyprolis™.

Relevant Publications:

Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU

ACS Chemical Biology 2016 11 6 1544-1551

Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM

ACS Chemical Biology 2012 7 12 2055-2063

Gough JD, Crews CM

Ernst Schering Research Foundation Workshop 2006 58 61-74

Yeh JR, Crews CM

Developmental Cell 2003 5 1 11-19

Koh B, Crews CM

Chemical Genetics: A Small Molecule Approach to Neurobiology Neuron 2002 36 4 563-566

Crews CM, Splittgerber U

Trends in Biochemical Sciences 1999 24 8 317-320