Publications

29. Crystal Structure of Epoxomicin: 20S Proteasome Reveals a Molecular Basis for Selectivity of α', β' -Epoxyketone Proteasome Inhibitors.
Groll M, Kim K, Kairies N, Huber R, Crews CM
J. Am. Chem. Soc. 2000 122():1237-1238
28. Proteasome Inhibition by the Natural Products Eponemycin and dihydroeponemycin: Insights into Specificity and Potency.
Kim K, Myung J, Sin N, Crews CM
Bioorg. Med. Chem. Lett. 1999 9(23):3335-3340
27. Towards Subunit specific Proteasome Inhibitors: Synthesis and Evaluation of Peptide α', β'-epoxyketones.
Elofsson M, Splittgerber U, Myung J, Crews CM
Chemistry & Biology 1999 6(11):811-822
26. Epoxomicin, a Potent and Selective Proteasome Inhibitor exhibits in vivo Anti-inflammatory Activity.
Meng L, Mohan R, Kwok BHK, Elofsson M, Sin N, Crews CM
Proc. Natl. Acad. Sci. USA 1999 96(18):10403-10408
25. Total Synthesis of the Potent Proteasome Inhibitor Epoxomicin: A Potential Tool for Understanding Proteasome Biology.
Sin N, Kim KB, Elofsson M, Meng L, Auth H, Kwok BHB, Crews CM
Bioorganic & Med. Chem. Letters 1999 9(15):2283-2288
24. Chemical Genetics: Exploring and Controlling Celular Processes with Chemical Probes.
Crews CM, Splittgerber U
Trends in Biochemical Sciences 1999 24(8):317-320
23. Eponemycin Exerts its Antitumor Effect through Inhibition of Proeasome Function.
Meng L, Kwok B, Sin N, Crews CM
Cancer Research 1999 59(12):2798-2801
22. Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin
Liu S, Widom J, Kemp CW, Crews CM, Clardy J
Science 1998 282(5392):1324-1327
21. The antiproliferative agent, didemnin B, uncompetitively inhibits palmitoyl protein thioesterase.
Meng L, Sin N, Crews CM
Biochemistry 1998 37(29):10488-10492
20. Eponemycin Analogs: Syntheses and use as probes of angiogenesis.
Sin N, Meng L, Auth H, Crews CM
Bioorganic and Med. Chem. 1998 6(8):1209-1217
19. Synthesis of 9-Fluorenylmethoxycarbonyl Protected Amino Aldehydes.
Wen JJ, Crews CM
Tetrahedron Asymmetry 1998 9(11):1855-1858
18. Tightening the Nuts and Bolts.
Elofsson M, Crews, CM
Trends in Biotechnology 1998 16():147-149
17. Towards the semi-synthesis of Didemnin M. Solution and solid phase synthesis of a pseudotetrapeptide: pGlu-GlnΨ [COO]Ala-Pro-OH.
Wen JJ, Crews CM
Tetrahedron Letters 1998 39(8):779-782
16. The anti-angiogenic agent fumagillin covalently binds and inhibits methionine aminopeptidase, Met AP-2.
Sin N, Meng L, Wang MQW, Wen JJ, Bornmann WG, Crews CM
Proc. Natl. Acad. Sci. USA 1997 94(12):6099-6103
15. Deciphering Isozyme Function: Exploring Cell Biology with Chemistry in the Post-Genomic Era.
Crews CM
Chemistry and Biology 1996 3(12):961-965
14. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
Crews CM, Lane WS, Schreiber SL
Proc. Natl. Sci. USA 1996 93(9):4316-4319
13. Mek1, Mapk/Erk Kinase
Erikson RL, Alessandrini AA, Crews CM
The Protein Kinase Facts Book 1995 ():275-277
12. GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 ​alpha.
Crews CM, Collins JL, Lane WS, Snapper ML, Schreiber SL
J. Biol. Chem 1994 269(22):15411-15414
11. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.
Brott BK, Alessandrini AA, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL
Cell Growth Differ. 1993 4(11):921-929
10. Raf-1 forms a stable complex with MEK1 and activates MEK1 by serine phosphorylation.
Huang W, Alessandrini AA, Crews CM, Erikson RL
Proc. Natl. Acad. Sci. USA 1993 90(23):10947-10951

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