Publications

69. Design and applications of bifunctional small molecules: why two heads are better than one.
Corson TW, Aberle N, Crews CM
ACS Chemical Biology 2008 3(11):677-692
68. Synthesis of the C3-C18 Frangment of Amphidinolides G and H.
Petri AF, Schneekloth JS, Mandal AK, Crews CM
Organic Letters 2007 9(16):3001-3004
67. Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials.
Corson TW, Crews CM
Cell 2007 130(2):769-774
66. Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease.
Leuenroth SJ, Okuhara D, Shotwell JD, Markowitz GS, Yu Z, Somlo S, Crews CM
Proc Natl Acad Sci USA 2007 103(11):4389-4394
65. Using Natural Products to Unravel Cell Biology. Chemical Biology: From Small Molecules to System Biology and Drug Design.
Gough J, Crews CM
Chemical Biology: From Small Molecules to System Biology and Drug Design. (Eds: S. Schreiber, TM Kapoor, G Weiss) 2007 ():
64. Construction of Highly Substituted Stereodefined Dienes by Cross-Coupling of α-Allenic Acetates.
Schneekloth JS JR., Puchaeult M, Crews CM
Eur. J. Org. Chemistry 2007 ():40-43
63. A chemical and genetic approach to the mode of action of fumagillin.
Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM
Chem Biol. 2006 13(9):1001-1009
62. Neurotrophic Peptide Aldehydes: Solid Phase Synthesis of Fellutamide B and a Simplified Analog.
Schneekloth JS Jr., Sanders JL, Hines J, Crews CM
Bioorg Med Chem Lett. 2006 16(14):3855-3858
61. Myriaporone 3/4 structure-activity relationship studies define a pharmacophore targeting eukaryotic protein synthesis.
Hines J, Roy M, Cheng H, Agapakis CM, Taylor R and Crews CM
Mol Biosyst 2006 2(8):371-379
60. Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest.
Yeh J-R, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM
Proc Natl Acad Sci USA 2006 103(27):10379-10384
59. Synthetic Studies on amphidinolide B1.
Mandal A, Schneekloth JS Jr., Kuramochi K, Crews CM
Organic Letters 2006 8(3):427-430
58. Studies on Calcium Dependence Reveal Multiple Modes of Action for Triptolide.
Leuenroth S, Crews CM
Chem Biol. 2005 12(12):1259-1268
57. Developing Microcolin A Analogues as Biological Probes.
Mandal A, Hines J, Crews CM
Bioorg. Med. Chem Letters 2005 15(18):4043-4047
56. Stereoselective Assembly of a 1,3-Diene via Coupling between an Allenic Acetate and a (B)-alkylborane: Synthetic Studies on Amhidinolide B1.
Mandal AK, Schneekloth JS Jr., Crews CM
Organic Letters 2005 7(17):3645-3648
55. Probing protein function with small molecules.
Gough JD, Crews CM
Ernst Schering Research Foundation Workshop 2006 (58):61-74
54. Development and characterization of proteasome inhibitors.
Kim KB, Fonseca F, Crews CM
Methods Enzymol 2005 399():585-609
53. Chemical approaches to controlling intracellular protein degradation.
Schnnekloth JS Jr., Crews CM
Chembiochem 2005 6(1):40-46
52. Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR.
Lin S, Yang ZQ, Kwok BH, Koldobskiy M, Crews CM, Danishefsky SJ
JACS 2004 126(20):6347-6355
51. Chemical genetic control of protein levels: selective in vivo targeted degradation.
Schneekloth JS Jr., Fonseca F, Koldobskiy M, Mandal A, Deshaies R, Sakamoto K, Crews CM
JACS 2004 126(12):3748-3754
50. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases.
Brdlik C, Crews CM
J. Biol. Chem. 2004 279(10):9475-9480

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