89. Natural Product Inhibitors of the Ubiquitin-Proteasome Pathway.
Schneekloth JS JR., Crews CM
Curr Drug Targets 2011 12(11):1581-1594
88. Targeted Intracellular Protein Degradation as a Potential Therapeutic Strategy.
Schneekloth A, Crews CM
New Frontiers in Chemical Biology: Enabling Drug Discovery (Mark Bunnage, Editor) 2010 ():
87. Total synthesis and biological evaluation of tyroscherin.
Tae HS, Hines J, Schneekloth AR, Crews CM
Org Lett 2010 12(19):4308-4311
86. Targeting the Undruggable Proteome: The Small Molecules of My Dreams.
Crews CM
Chemistry & Biology 2010 17(6):551-555
85. Reversal of TNP-470-Induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides.
Hines J, Ju R, Dutschman GE, Cheng YC, Crews CM
J Pharmacol Exp Ther 2010 334(3):729-738
84. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis.
Ju R, Cirone P, Lin S, Griesbach H, Slusarski DC, Crews CM
Proc. Natl. Acad. Sci. USA 2010 107(15):6906-6911
83. Identification and characterization of a peptidic ligand for Ras.
Gareiss PC, Schneekloth AR, Salcius MJ, Seo SY, Crews CM
Chembiochem 2010 11(4):517-522
82. Chemical inducers of targeted protein degradation.
Raina K, Crews CM
J. Biol. Chem. 2010 285(15):11057-11060
81. Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F, Crews CM
Nephrol Dial Transplant 2010 25(7):2187-2194
80. Total synthesis and structure-activity investigation of the marine natural product neopeltolide.
Custar DW, Zabawa TP, Hines J, Crews CM, Scheidt KA
J. Am. Chem. Soc. 2009 131(34):12406-12414
79. Targeting cyst initiation in ADPKD.
Leuenroth SJ, Crews CM
J. Am. Soc. Nephrol 2009 20(1):1-3
78. Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer.
Rodriguez-Gonzalez A, Cyrus K, Salcius M, Kim K, Crews CM, Deshaeies RJ, Sakamoto KM
Oncogene 2008 27(57):7201-7211
77. Proteasome Inhibition by fellutamide B induces nerve growth factor synthesis.
Hines J, Groll M, Fahnestock M, Crews CM
Chemistry & Biology 2008 15(5):501-512
76. A role for planar cell polarity signaling in angiogenesis.
Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM
Angiogenesis 2008 11(4):347-360
75. Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.
Schnnekloth AR, Pucheault M, Tae HS, Crews CM
Bioorg. Med. Chem. Lett. 2008 18(22):5904-5908
74. Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure.
Leuenroth SJ, Crews CM
Cancer Research 2008 68(13):5257-5266
73. Triptolide Reduces Cystogenesis in a Model of ADPKD.
Leuenroth SJ, Bencivenga N, Igarishi P, Somlo S, Crews CM
J. Am. Soc. Nephrology 2008 19(9):1659-1662
72. Proteasome Inhibitors in Cancer Chemotherapy.
Molineaux CJ, Crews CM
Cancer, Principles & Practice of Oncology (Eds: VT Devita, TS Lawrence and SA Rosenberg) 2008 8th Edition(Chapter 25):486-490
71. Chemical Genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors.
Kim KB, Crews CM
J. Med Chem 2008 51(9):2600-2605
70. Wound Epidermis Formation and Function in Urodele Amphibian Limb Regeneration.
Campbell LJ, Crews CM
Cellular and Molecular Life Sciences 2007 65(1):73-79