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Waste Disposal- An attractive strategy for cancer therapy

Salami J, Crews CM
Science 2017 355(6330):1163-1167

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy

Ottis P, Crews CM
ACS Chemical Biology 2017 10.1021/acschembio.6b01068():

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells. 

Saenz DT, Fiskus W, Qian Y, Manshouri T, Rajapakshe K, Raina K, Coleman KG, Crew AP, Shen A, Mill CP, Sun B, Qiu P, Kadia TM, Pemmaraju N, DiNardo C, Kim MS, Nowak AJ, Coarfa C, Crews CM, Verstovsek S, Bhalla KN.
Leukemia 2017 (advanced online publication):

Induced Protein Degradation: An Emerging Drug Discovery Paradigm.

Lai AC, Crews CM
Nature Reviews Drug Discovery 2017 16():101-114

Targeted Protein Degradation by Small Molecules.

Bondeson DP, Crews CM
Annual Review of Pharmacology and Toxicology 2017 57():107-123

Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent.

Toure M, Jaime-Figueroa S, Burslem G, and Crews CM
European Journals of Organic Chemistry 2017 ():

Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity of Monastrol-Treated Cells

Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU
ACS Chemical Biology 2016 11(6):1544-1551

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Raina K, Lu J, Qian Y, Altieri M, Gordon D, Rossi AMK, Wang J, Chen X, Dong H, Siu K, Winkler JD, Crew AP, Crews CM, and Coleman KG
Proc Natl Acad Sci, USA 2016 ():

Small-Molecule PROTACS: New Approaches to Protein Degradation.

Toure M, Crews CM
Angewandte Chemie International Edition 2016 55():2-10

Accessing Oncogenic BCR-ABL for Degradation by Modular PROTAC Design.

Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM
Angewandte Chemie International Edition 2016 55(2):807-810

Small-Molecule-Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging. 

Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg B, Hines J, McDonnell DP, Norris JD, Crews CM.
Angewandte Chemie Int. Ed. Engl. 2015 doi:10.1002/anie.201503720():

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.

Buckley DL, Raina K, Darricarrerre N, Hines J, Gustafson JL, Smith IE, Miah AH, Harling JD, Crews CM
ACS Chemical Biology 2015 doi:10.1021/acschembio.5b00442():

Development of small molecules targeting the pseudokinase Her3.

Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Janne PA, Crews CM, Gray NS
Bioorganic and Medicinal Chemistry Letters 2015 doi:

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Bondeson DP, Mares A, Smith IED, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Sruidenier L, Carter PS, Harling JD, Churcher I, & Crews CM
Nature Chemical Biology 2015 doi:10.1038/nchembio. 1858():

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, Hines J, Winkler JD, Crew AP, Coleman K, Crews CM
Chemistry & Biology 2015 22():1-9

Targeted Protein Destabilization Reveals an Estrogen-mediated ER Stress Response.

Raina K, Noblin DJ, Serebrenik YV, Adams A, Zhao C, Crews CM.
Nature Chemical Biology 2014 10(11):957-962

Highly Efficient Targeted Mutagenesis in the Axolotl using Cas9 RNA-guided Nuclease.

Flowers GP, Timberlake AT, Mclean KC, Monaghan JR, Crews CM.
Development 2014 141(10):2165-2171

Pharmacological Targeting of the Pseudokinase Her3

Xie T, Lim SM, Westover K, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Riddle SM, Marto JA, Janne PA, Crews CM, Gray NS
Nature Chemical Biology 2014 10():1006-1012

Small Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System.

Buckley DL, and Crews CM
Angewandte Chem. Int. Ed. 2014 53(9):2312-2330