Skip to main content



Highly Efficient Targeted Mutagenesis in the Axolotl using Cas9 RNA-guided Nuclease.

Flowers GP, Timberlake AT, Mclean KC, Monaghan JR, Crews CM
Development 2014 ():

Small Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System.

Buckley DL, and Crews CM
Angewandte Chem. Int. Ed. 2014 53(9):2312-2330

A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins.

Neklesa TK, Noblin DJ, Kuzin A, Lew S, Seetharaman J, Acton TB, Kornhaber G, Xiao R, Montelione GT, Tong L, Crews CM.
ACS Chemical Biology 2013 8(10):2293-2300

From epoxomicin to carfilzomib:chemistry, biology, and medical outcomes.

Kim KB, Crews CM
Natural Product Reports 2013 30(5):600-604

Posttranslational Protein Knockdown Coupled to Receptor Tyrosine Kinase Activation with PhosphoPROTACs.

Hines J, Grough JD, Corson TW, Crews C
Proc Natl Acad Sci U.S.A. 2013 110(22):8942-8947

A HaloTag-based Small Molecule Microarray Screening Methodology with Increased Sensitivity and Multiplex Capabilities

Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM
ACS Chemical Biology 2012 7(12):2055-2063

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM
Angew. Chem. Int. 2012 51(46):11463-11467

Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

Van Molle I, Thomann A, Buckley DL, So EC, Lang S, Crews CM, Ciulli A
Chemistry & Biology 2012 19():1300-1312

Greasy tags for protein removal.

Neklesa TK, Crews CM
Nature 2012 487(19):308-309

Targeting the von Hippel-Lindau E3 Ubiquitin Ligase using Small Molecules to Disrupt the VHL-HIF-1alpha Interaction.

Buckley DL, Van Molle I, Gareiss PC, Tae H-S, Miche J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM
J. Am. Chem. Soc 2012 134(10):4465-4468

Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration

Holman EC, Campbell LJ, Hines J, Crews CM
PLOS|One 2012 7(9):1-10

Identification of Hydrophobic Tags for Degradation of Stabilized Proteins.

Tae H-S, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM
ChemBioChem 2012 13(4):538-541

Gene expression profile of the regeneration epithelium during axolotl limb regeneration.

Campbell LJ, Suárez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM
Dev Dyn 2011 240(7):1826-1840

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.

Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S
Nat Genet 2011 43(7):639-647

Proteasome Inhibitors.

Kauffman MG, Molineaux CJ, Kirk CJ, Crews CM
Cancer: Principles & Practice of Oncology (Eds., Devita VT, Lawrence TS, Rosenberg SA, DePinho RA) 2011 Chapter 41():441-449

Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37.

Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Clusarski DC, Beynon RJ, Crews CM
Chemistry & Biology 2011 18(10):1300-1311

Triptolide Directly Inhibits dCTP pyrophosphatase.

Corson TW, Cavga H, Aberle N, Crews CM
ChemBioChem 2011 12(11):1767-1773

Small-molecule hydrophobic tagging-induced degradation of HaloTag Fusion proteins.

Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM
Nat Chem Biol 2011 7(8):538-43

Unexpected stereochemical tolerance for the biological activity of tyroscherin.

Tae HS, Hines J, Schneekloth AR, Crews CM
Bioorg Med Chem 2011 19(5):1708-1713

HIV protease-mediated activation of sterically capped proteasome inhibitors and substrates.

Buckley DL, Corson TW, Aberle N, Crews CM
J Am Chem Soc 2011 133(4):698-700