Craig Crews Biosketch

CRAIG MARTIN CREWS, Ph.D.

Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology
Department of Chemistry
Department of Pharmacology
Yale University

Education

1987-1993 Ph.D., Biochemistry, Harvard University, with Dr. R.L. Erikson
1986-1987 DAAD Fellow, Universität Tübingen, Germany
1982-1986 B.A., Chemistry, (minor in Biology), University of Virginia

Professional Experience

2015 Director, Program for Innovative Therapeutics for Connecticut’s Health (PITCH)
2013 Founder, Arvinas LLC (oncology-focused biotech)
2010 Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology
2003 Co-Founder, Proteolix, Inc. (sold to Onyx Pharmaceuticals, 2009)
2003 Executive Director, Yale Small Molecule Discovery Center
2003 PI, NIH T32 Chemistry and Biology Interface (CBI) Training Grant (T32GM067543)
2001-2007 Associate Professor, Yale University, Dept of Chemistry
1998-2007 Assistant Professor, Yale School of Medicine, Dept of Pharmacology
1995-2007 Assistant Professor, Yale University, Dept of Molecular, Cellular & Developmental Biology (tenured 2001)
1993-1995 Postdoctoral Fellow, Dept. of Chemistry, Harvard University, with Dr. Stuart Schreiber

Honors and Awards

2017 AACR Award for Outstanding Achievement in Chemistry in Cancer Research
2015 Translational Research Prize, Yale Cancer Center
2015 NIH R35 Outstanding Investigator Award (National Cancer Institute)
2014 UCB-Ehrlich Award for Excellence in Medicinal Chemistry (Eur. Fed. of Med. Chemistry)
2013 Entrepreneur of the Year, Connecticut United for Research Excellence (CURE)
2013 Fellow, American Association for the Advancement of Science (AAAS)
2011 Senior Scholar Award, Ellison Medical Foundation
2010-2013 Visiting Professor (Gast Professor), Universität Konstanz, Germany
2010 Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology
2006 Bessel Research Award, Alexander von Humboldt Foundation, Germany
2005- Fellow of the Royal Society of Chemistry
1999 Arthur Greer Memorial Prize (Outstanding Junior Faculty in the Social or Natural Sciences)
1996-1998 CaPCURE Research Award (Association for the Cure of Cancer of the Prostate)
1996-1999 Burroughs Wellcome Fund New Investigator Award
1993-1995 Cancer Research Institute Postdoctoral Fellowship
1986-1987 DAAD Research Fellowship (German Academic Exchange Service)

Editorial Boards

2015 Editorial Board, ACS Chemical Biology
2010 Editorial Board, ChemBioChem
2008- Editor, Cell Chemical Biology (formerly Chemistry & Biology)
2005-2009 Editorial Board, Molecular Biosystems
2001- Editorial Board, Cell Chemical Biology (formerly Chemistry & Biology)
2001-2005 Editorial Board, Faculty of 1000
2001-2009 Editorial Board, Molecular and Cellular Proteomics

Patents

‘Enzyme Inhibition’ Patent US 6,831,099 B1
‘Enzyme Inhibition’ Patent US 7,476,650
‘Proteolysis-Targeting Chimeric Pharmaceutical’ Patent US 7,041,298
‘Proteolysis-Targeting Chimeric Pharmaceutical’ Patent US 7,208,157
‘Compounds for Enzyme Inhibition’ Patent US 7,232,818
‘Compounds for Enzyme Inhibition’ Patent US 7,491,704
‘Compounds for Enzyme Inhibition’ Patent US 8,088,741
‘Compounds for Enzyme Inhibition’ Patent US 8,129,346

FDA Approved Drugs

Carfilzomib/Kyprolis™ (based on the YU101 structure): approved for relapsed multiple myeloma (7/20/12)

Laboratory Website

crewslab.yale.edu

Complete CV